We investigate the complex interactions between biopolymers peptides, proteins, DNA, RNA, lipids, and carbohydrates in order

to understand cellular physiology at the molecular level. Our research at URI has focused on using solid-phase peptide

synthesis (SPPS) to prepare diverse combinatorial libraries of both naturally-occurring and engineered peptides for

further study. We have designed antimicrobial peptides (AMPs) based upon pleurocidin, isolated from Winter Flounder,

to combat the growing problem of antimicrobial resistance in pathogenic microbes, and topoisomerase inhibitors

based on natural products for use in cancer chemotherapy. Our bioanalytical chemistry research has involved the development

of novel methods for monitoring dynamic properties of peptides, proteins, lipids and DNA using capillary electrophoresis (CE),

circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopy. The molecular modeling/bioinformatics research

area aims to expand the application of molecular mechanic techniques in order to model dynamic processes

in the biopolymers we investigate.

Creating AMPed

Our database is created to have all the related information about the Antimicrobial Peptides so that it can serve as a hub for

researchers. Data curation is the difficult phase of creating database which takes time and effort. We are on high road

to make efforts for collaboration around the world with researchers having same research field to collect data which in turn

will help in experiments, creating and using tools for better outcome. Gradually updating every aspect of database as needed.

We aspire to be as “Brenda database” is for Enzyme, "AMPed" for Antimicrobial Peptide.